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| 50 ml NOK 500 |
Natural Acne Treatment er basert på et derivat-ekstrakt (glycyrrhetinic acid) fra lakrisplanten (glycyrrhiza glabra) blandet med hjelpestoffer som frakter glycyrrhetinic acid gjennom huden og inn i sebocyttene.
Acne forårsakes av testosteron som binder seg til androgenreseptoren (AR). Det setter i gang høy sebocytt-proliferasjon/turnover og holokrin sebumsekresjon. Bakterier lever på avfall fra disse sprengte cellene og setter i gang en infeksjon/betennelse som gir acne.
Glycyrrhetinic acid i Natural Acne Treatment blokkerer/nedregulerer androgenreseptoren og gir en varig reduksjon av acne og sorte prikker. (Bilde/link under)
Smøres på hudområder med acne/sorte prikker.
https://pubmed.ncbi.nlm.nih.gov/32219716/
Ingredients: paraffinum liquidum,
phenoxyethanol, parfum, glycerin,
cetearyl alcohol, glyceryl stearate se,
prunus amygdalus dulcis oil, aqua,
ethylhexylglycerin, panthenol, cetyl
alcohol, ceteareth-25, disodium EDTA,
ammonium acryloyl-dimethyltaurate/
VP copolymer, glycyrrhiza glabra,
glycyrrhetinic acid.
Natural colour: tan
Trekker raskt inn i huden og blir usynlig.
For bestilling av 50 ml Natural Acne Treatment (se bilde) direkte til Deres postkasse for kr 500,- inkl. frakt, send navn og adresse til:
ottarstensvold@hotmail.com
ev. SMS til: 95177433
Betaling via nettbank eller Vipps.
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| Glycyrrhetinic acid (GA) blokkerer androgenreseptoren (AR) |
Bilde fra Wikipedia.
Attribution: Figure by Jonathan Marcus, based on an original drawing by Dr. Marianne D Sadar (Meehan KL, Sadar MD. Front Biosci. 2003 May 1;8:d780-800).
https://pubmed.ncbi.nlm.nih.gov/32219716/
English translation of this revolutionary new invention:
Natural Acne Treatment is based on a derivative-extract (glycyrrhetinic acid) from the licorice plant (glycyrrhiza glabra) mixed with excipients that carry glycyrrhetinic acid through the skin and into the sebocytes.
Acne is caused by testosterone binding to the androgen receptor. This triggers high sebocyte proliferation/turnover and holocrine sebum secretion. Bacteria live on debris from these ruptured cells and give infection/inflammation which causes acne.
The glycyrrhetinic acid in Natural Acne Treatment blocks/downregulates the androgen receptor and provides a lasting reduction of acne and blackheads. (Picture/link)
Soft cream. Goes quickly into the skin and becomes invisible.
Apply to areas of skin with acne/blackheads.
To order 50 ml Natural Acne Treatment directly to your mailbox for NOK 500, - (free shipping), send name and address to:
ottarstensvold@hotmail.com
ev. to SMS: +47 95177433
https://pubmed.ncbi.nlm.nih.gov/32219716/
Invented by Ottar Stensvold
Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells
SvarSlettYou Sun et al. Arch Pharm Res. 2020 Apr.
Hide details
Arch Pharm Res
. 2020 Apr;43(4):433-448.
doi: 10.1007/s12272-020-01228-z. Epub 2020 Mar 26.
Authors
You Sun 1, Mingyue Jiang 1, Pil-Hoon Park 2, Kyung Song 3 4 5 6
Affiliations
1Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea.
2Department of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.
3Department of Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea. kyungsong@wku.ac.kr.
4Institute of Pharmaceutical Research and Development, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea. kyungsong@wku.ac.kr.
5Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea. kyungsong@wku.ac.kr.
6Integrated Omics Institute, Wonkwang University, 54538, Iksan, Jeollabuk-do, Republic of Korea. kyungsong@wku.ac.kr.
PMID: 32219716
DOI: 10.1007/s12272-020-01228-z
Full text links
Cite
Erratum in
Correction to: Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells.
Sun Y, et al. Arch Pharm Res. 2020. PMID: 32737847
Abstract
Androgen receptor (AR) plays a pivotal role as a target for amplification/mutation in pathogenesis and tumor progression in prostate, and thus, controlling AR activity or expression might be a feasible therapeutic approach for the treatment of prostate cancer. Here, we report the novel mechanisms by which 18β-glycyrrhetinic acid (GA) targets AR to stimulate cell death in both hormone-responsive and -refractory prostate cancer cells. We found that miR-488, a tumor suppressive microRNA, was markedly induced by GA treatment, resulting in the down-regulation of AR expression and inhibition of cellular responses mediated by androgens. Moreover, GA not only suppressed the expression of androgen target genes (TMPRSS2, PSA, and NKX3.1), but also enhanced the suppressive effect of anti-androgens (bicalutamide and flutamide) on LNCaP cell growth. Our data further provides evidence that down-regulation of AR expression by GA may occur through transcriptional suppression at AR promoter region between - 1014 and - 829. Ectopic expression of SFR and E2F3α reversed the inhibitory effect of GA on AR promoter activity as well as protein expression, suggesting that GA may target transcription factors SRF and E2F3α to regulate AR expression. Taken together, our study provides new insights on AR regulation and GA as a potential therapeutic candidate for human prostate cancer.
Keywords: 18β-glycyrrhetinic acid; Androgen receptor; E2F3; SRF; Transcriptional suppression; miR-488.
From:
https://pubmed.ncbi.nlm.nih.gov/32219716/
"Glycyrrhizin and glycyrrhetinic acid inhibited the conversion
SvarSlettof androstenedione to testosterone, indicating that these compounds inhibit the activity of 17β-hydroxysteroid dehydrogenase"
(KENJI SAKAMOTO AND KATSUMI WAKABAYASHI)
And since 17β-hydroxysteroid dehydrogenase is present in sebocytes, glycyrrhetinic acid can inhibit testosteronee synthesis in sebaceous glands.
https://pubmed.ncbi.nlm.nih.gov/11348472/